![]() ![]() In the training cohort, the areas under the curve were 0.708 for 3-year survival and 0.704 for 5-year survival. The time-dependent receiver operating characteristic curve analysis suggested that the 8-gene signature had a good predictive accuracy. Results In this prognostic study based on samples from 1096 women with BC (mean age, 59.6 years), 8 DRGs ( MDC1, RPA3, MED17, DDB2, SFPQ, XRCC4, CYP19A1, and PARP3) were identified as prognostic biomarkers. To examine the potential mechanisms of the DRGs, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed. Finally, a prognostic nomogram, combining the DRG signature and clinical characteristics of patients, was constructed. A risk model was completely established through multivariate Cox proportional hazards regression analysis. Main Outcomes and Measures Primary screening prognostic biomarkers were analyzed using univariate Cox proportional hazards regression analysis and the least absolute shrinkage and selection operator Cox proportional hazards regression. A prognostic signature based on 8 DNA repair–related genes (DRGs) was developed to predict overall survival among female patients with BC. This study consisted of a training set from The Cancer Genome Atlas database and 2 validation cohorts from the Gene Expression Omnibus, which included 1096 patients with BC. Objectives To identify a potential DNA repair–related prognostic signature through a comprehensive evaluation and to further improve the accuracy of prediction of the overall survival of patients with BC.ĭesign, Setting, and Participants In this prognostic study, conducted from October 9, 2019, to February 3, 2020, the gene expression profiles and clinical data of patients with BC were collected from The Cancer Genome Atlas database. Currently, identifying effective prognostic models has a significant association with the prediction of the overall survival of patients with BC and guidance of clinicians in early diagnosis and treatment. Importance Breast cancer (BC), a common malignant tumor, ranks first among cancers in terms of morbidity and mortality among female patients. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography. ![]() The Functional Enrichment Analysis Included KEGG Pathway (A) and Biological Process (B) The functional Enrichment Analysis Included GO Pathway (A) and Biological Process (B)ĮFigure 6. The Calibration Plots for Predicting Patient 3-Year (A) and 5-Year (B) Overall SurvivalĮFigure 5. ROC Curves and Kaplan-Meier Plots of Overall Survival in External Validation CohortsĮFigure 4. Eight DRGs Were Selected to Construct Prediction Model by Multivariate Cox Regression AnalysisĮFigure 3. Heatmap of Differentially Expressed Genes Between BC Tissues and Normal ControlsĮFigure 2. KEGG Pathways Enriched in High-Risk and Low-Risk Groups by Using GSEAĮFigure 1. The 33 DNA Repair-Related Genes Identified Through the Univariate Cox AnalysisĮTable 6. Clinic Pathological Characteristics of Extracted Patients With Breast CancerĮTable 5. Checklist of Items for Reporting a Study Developing or Validating a Multivariable Prediction ModelĮTable 2. ![]()
0 Comments
![]() ![]() ![]() Analyze historical currency charts or live British pound sterling / Pakistani rupee rates and get free rate alerts directly to your email.1 GBP = 368.3521 PKR Save 3-5% on your Pounds to Pakistani Rupees money transfer today The live Pound to Pakistani Rupee exchange rate (GBP PKR) as of at 7:57 PM. Convert 1092 GBP to PKR with the Wise Currency Converter. Sign up for free exchange rate alerts or just get daily/weekly rates and news to your inbox? Compare the best travel money rates against the high street below. For commercial purposes, get an automated currency feed through the …1 GBP = 368.3521 PKR Save 3-5% on your Pounds to Pakistani Rupees money transfer today The live Pound to Pakistani Rupee exchange rate (GBP PKR) as of at 7:57 PM. Analyze historical currency charts or live British pound sterling / Pakistani rupee rates and get free rate alerts directly to your email.BEST RATE Read more about Remitly ★★ ★★ ★★ ★★ ★ Read all reviews (5) 1000 GBP = 371 370.00 PKR Transfer Limit (GBP): 0 - 20000 Locked-In Rate 1 GBP = 371.3700 PKR Send money now Get a special exchange rate Get one free transfer □ Special exchange rate applied for first transfer Read more about Western Union ★★ ★★ ★★ ★★ ★★ Read all reviews (15) This PKR currency table offers historic Pakistani Rupee rates compared to every world currency. Convert 800 GBP to PKR with the Wise Currency Converter. Important information The Best Deal Important info > 192,732 Reviews 4.3 Get a rate guarantee with Wise Total £539.33 GBP Go to site Rates updated less than 1 min agoGet the latest Pound sterling to Pakistani Rupee (GBP / PKR) real-time quote, historical performance, charts, and other financial information to help you make more informed trading and investment. The exchange rate of the British …Looking to send money from United Kingdom to Pakistan instead? We only compare secure providers which we have researched, tested and approved. The cost of 150 British Pounds in Pakistani Rupees today is ₨52,613.85 according to the “Open Exchange Rates”, compared to yesterday, the exchange rate decreased by -0.09% (by -₨0.33). ![]() ![]() ![]() Medications - Drugs like Ephedrine are recommended to speed up the nervous system. Your body processes caffeine very slowly until delivery, and the metabolism gets better after the child is born. Pregnancy - During the third trimester, the enzyme that helps in caffeine metabolism reduces, increasing the half-life of caffeine. Some smokers have almost two times caffeine metabolism rates than non-smokers. Smokers have very high caffeine metabolism rates and can usually handle high amounts of caffeine easily. Smoking - Smoking clears caffeine from the body very quickly. Grapefruit decreases caffeine clearance by about 23%īroccoli increases caffeine clearance in the plasmaįruits and vegetables rich in flavonoid affects caffeine metabolism rates Eating such food before you consume caffeine can make changes in caffeine metabolism. Leaner individuals can increase their calories burnt by 30% when compared to overweight individuals (increase calories burnt by 10%) when they consume caffeine.ĭiet - Few types of foods increase or decrease caffeine clearance in the body. Weight - Caffeine metabolism also depends on body weight. The more severe your liver disease is the lower the caffeine metabolism rate. People with liver diseases like liver cirrhosis, hepatitis B, or hepatitis C have lowered plasma clearance rates of caffeine. Liver diseases - Many studies relate liver diseases to lowered caffeine metabolism. Non-genetic Factors Affecting Caffeine Metabolism They may be prone to the side-effects of caffeine consumption. The CT and the TT genotype individuals are slow metabolizers. Those with the CC genotype metabolize caffeine very rapidly and may not be affected by the negative effects of caffeine consumption. ![]() Rs11854147 of CYP1A2 Gene and Caffeine MetabolismĪnother SNP that causes an increase/decrease in caffeine metabolism is the rs11854147. They experience the unpleasant side effects of caffeine consumption, and their bodies process caffeine very slowly. Individuals with the AA genotype process caffeine quickly and may not experience the negative side-effects of caffeine consumption.īoth the AC genotype and the CC genotype individuals are slow metabolizers. The AA genotype of this SNP is associated with faster metabolism of caffeine. The rs762551 SNP is the most discussed variation in the CYP1A2 gene. Rs762551 of CYP1A2 Gene and Caffeine Metabolism There are a few types of variations in this gene that affects how your body responds to caffeine. This enzyme plays an important role in caffeine metabolism. This is responsible for breaking down drugs, hormones, and other chemicals in the body to help retain essential parts and eliminate waste. The CYP1A2 gene produces the CYP1A2 enzyme. How Does Genetics Influence Caffeine Metabolism CYP1A2 gene People develop a better tolerance for caffeine when they consume it regularly.Īpart from developed tolerance, other factors like genetics, age, lifestyle, and diet also affect the rate of metabolism of caffeine. This prevents adenosine from acting and keeps people active and fatigue-less. Caffeine attaches itself to the adenosine receptors. Adenosine receptors usually absorb adenosine. Adenosine helps the brain relax and sleep. The structure of caffeine is similar to that of adenosine. The half-life can increase or decrease depending on both genetic and non-genetic factors.Ĭaffeine easily crosses the blood-brain barrier. The half-life of caffeine is about 4 hours. Half-life is the amount of time it takes for caffeine to be reduced to half its initial levels. The liver breaks down caffeine with the help of certain enzymes. The peak levels of caffeine in the plasma are reached in just 30 minutes. ![]() It takes just a few minutes for the caffeine to be fully absorbed by the human body. The tissues that line your blood vessels, skin, and organs let caffeine pass through quite easily. When you consume caffeine, it enters the bloodstream through your mouth, throat, and stomach. Caffeine Metabolism At Its Molecular Level - Getting Technical Metabolism is the process of converting the food you eat into energy. The difference lies in how your body metabolizes caffeine. While some individuals feel active, happy, and energetic after consuming caffeine, others feel anxious, uncomfortable, and stressed. This is why you feel ‘happy/good’ when you drink a cup of coffee or tea. Psychostimulants are substances that alter the mood and behavior of a person.Ĭaffeine is majorly present in coffee, tea, energy drinks, and chocolates.Ĭaffeine produces a small rise in dopamine levels in the brain. Caffeine is one of the most popular psychostimulants legally consumed. ![]() ![]() The bootable Standalone Recovery Manager enables users to recover a drive image from either a CD/DVD drive, a direct attached drive, or a network attached drive. Once complete, the WD Discovery app will still display OPEN. Follow the Installation prompts provided in Acronis True Image for Western Digital. Follow the article to download and install Acronis True Image for Western Digital.
![]() ![]() Here are the steps on how to completely remove GIMP from Mac: Additionally, it allows you to easily change startup programs, remove extensions and change default apps for different types of files. App Cleaner & Uninstaller also finds service files of already removed applications and displays them in the Remaining Files tab. How to remove GIMP from Mac using App Cleaner & UninstallerĪpp Cleaner & Uninstaller is a utility that uninstalls applications from Mac with all of its support files. That’s why we recommend that you uninstall applications with App Cleaner & Uninstaller, which automatically finds all the remaining files and removes applications completely. Since each user might have a different number of remaining files depending on his/her preferences, the period of time he/she used the application and other parameters, it might be not so quick to find all of the support files. Please note, we also recommend checking these folders in the Library for the remaining files: After removing all of the GIMP’s support files, empty your Trash bin and restart your system.~/Library/Saved Application State/-2.10/.savedState.Type ~/Library there and click on Go.Ĭheck the following directories for the GIMP support files: It will open the “Go to Folder” search field. To open this folder in Finder press the Command+Shift+G shortcut. By default, applications store their support files in the hidden folder named Library. Find the GIMP application and move it into the Trash. Open Finder and go to the Applications folder.You can do it right from the Dock panel or go to the GIMP menu and click on Quit GIMP – 2.10. Step-by-step guide.įollow the steps below to remove GIMP 2.10 with its service files from Mac: Below you can have a detailed step-by-step guide on how to find these support files and fully remove the GIMP application from your computer. Remove the GIMP executable file from the Applications folder.Ĭheck the ~/Library folder for the GIMP’s service files and remove all of the leftovers:Īs you can see, the important part of application uninstallation is to find and remove their support files.Here are three main steps on how to completely uninstall GIMP or any other application from Mac: You can completely uninstall GIMP using the manual method or do this in a few clicks with App Cleaner & Uninstaller.Ī quick guide on how to completely uninstall GIMP from Mac.Before writing this article, we checked the GIMP website for the removal instruction and did not find any.We used App Cleaner & Uninstaller and Funter to check the Mac for applications’ remaining files. However, if you have downloaded an application not from the App Store, they might spread out their service files all over your disk. By default, applications store their support files in the ~/Library folder. ![]() For the complete removal of applications from Mac, it is important to find and remove all of its support files from your system.You should always close the application before the removal process to prevent bumps on the road of an app uninstallation.Important notes and the methodology used to prepare GIMP uninstalling guide: ![]() ![]() ![]() You may want to keep your environment up-to-date with the latest Node.js releases. Please check its version as well to confirm the availability. To check its presence, you can query the version of it, node -v You have installed Node.js successfully on ubuntu. Now, we can use the apt tool to install Node.js. The s and L switch of curl shows an error if the request fails and follows the HTTP redirects. Now use the following command to get the Node.js PPA and add it to the local system. But before that, let's install curl(assuming it is not installed already). Let us use curl to get the Node.js PP downloaded. First, using the Node.js PPA.Ĭurl is a command-line utility to transfer data over the network. Using a tool called Node Version Manager(NVM).Manually by adding the Node.js PPA and use the apt command-line tool to install.We can install Node.js on Ubuntu in a couple of ways. If you are inserted in knowing other PPAs, you can search them here. The apt is Advanced Package Tool that helps to install, remove apps on Ubuntu.Īs you must have guessed now, Node.js PPA is available to use for installing it on the Ubuntu operating system. It allows you to upload Ubuntu source packages to be published as an apt repository. Ubuntu PPA: PPA is the short form of Personal Package Archive. You may find this image helpful in understanding Ubuntu's release cycles, versioning. Here also, the LTS releases are suitable for enterprises. ![]() Ubuntu LTS Version: Similarly, Ubuntu also has the LTS(Long Term Support) versions like Ubuntu 20.04 LTS that releases every two years in April. There is also a Nightly build available every 24-hours when there are changes. The Current version is the Node.js release under active development for an upcoming major release. If you plan to use Node.js in an enterprise app, you may opt for an LTS version. The releases with this version focused on stability and security. The term LTS stands for Long Term Support. On the download page, you will find two types of versions, LTS and Current. Node.js Versioning: One of the things I was confused about initially was Node.js versioning. Usually, these terminologies are used as shortcuts and could be confused to a beginner. It's essential to clarify a few terminologies around Node.js and Ubuntu. Please feel free to skip this section if you are already aware or want to directly get to the installation commands. In this article, we will learn to install, manage Node.js on the Ubuntu operating system so that you can quickly run a web application. It is available for the hobbyist, enterprises, desktops, and the cloud. On the other side, Ubuntu is an open-source operating system on Linux. It provides and supports the NPM(Node Package Manager) environment that is widely used today. As a web developer, you may find Node.js as omnipresent irrespective of client-side or server-side development. Node.js is a JavaScript runtime built on Chrome's V8 engine that helps to build scalable applications. ![]() ![]() ![]() Reddit, r/investing and its moderators assume no responsibility for the accuracy, completeness or objectivity of the information presented on r/investing. A huge list of the best books on investing.Full of excellent links to videos, articles, and books. A guide to stock research! - A hedge fund analyst explains his stock research process.Use the search function or check out this, this, this, this, this or this thread. This has been asked and answered many times in the past. I'm new to investing, what should I do?.Should I invest a lump-sum, or wait? It's about time in the market, not market timing & Vanguard's thoughts on lump-sum investing.WSJ guide on how to pick a financial planner.How do I get started in the Stock Market?. ![]() Bans will be issued without warning.Īdditional guidelines can be found at investing/wiki/index/rules. Responding to questions in bad faith, brigading, spreading misleading and false information, stock promotions from dedicated accounts are not permitted. Good faith discussions and comments only. This rule will be more strictly enforced based on how clickbaity an article is.Ĩ. Provide the link to the source article or paper. If anyone is writing an article based on a Bank/investment group news release/white paper post the actual paper and not journalism surrounding it. This means if CNBC is reporting on something WSJ reported on we expect you to post the original article. Original Sourcing: articles posted must be from the original source on a best efforts basis. There is a 250 character requirement for posts.ħ. Making your own post devoid of in depth examination will likely result in it being removed. "now is the time to buy", "here's my thoughts", etc. Do not post just an article, highlight the parts of the article you find relevant or offer some commentary surrounding the article.Īdditionally do not just make a self post to offer some simple thoughts. Effort: Posts must meet standards of effort. Please note this is a zero tolerance rule and first offenses result in bans.Ħ. Posts that are strictly self-interested or intended to "build awareness" are not acceptable.ĥ General corporate news and political posts must follow these guidelines. We generally expect that people who come here are not using the forum to build a brand, generate clicks, or shill. Do not post your youtube, twitter, discord, app, tool, blog, referral code, event, survey, etc. Violating this rule results in an automatic permanent ban. Strictly no (self-)promotion or solicitation threads. However, personal attacks, insults, trolling, or accounts dedicated to getting under the skin of others is not allowed, and will be banned.Ĥ. We recognize that this forum will generate differences of opinion, or misunderstandings of facts, and therefore arguments are expected. Off topic comments, attacks or insults will not be tolerated. ![]() Keep discussions civil, informative and polite. If your question likely has a "right answer", a beginner topic, you simply need help finding general investing information, or if it's asking for general input on what to do with your investments then post in the " Daily Advice and Discussion Thread".ģ. Do not make posts looking for advice about your personal situation. We generally expect that your topic incites responses relating to investing.Ģ. We are not a politics or general corporate news forum. Share investment ideas and insights or ask thoughtful investing discussion questions. ![]() ![]() ![]() ![]() ![]() The 2023 Kansas City Jazz Summit and Basically Basie Competition will be open for in-person performances based on the Covid-19 situation at the time of the event. The "Basically Basie" competition is more about determining which band embraced the "study" of the repertoire and demonstrated their "findings" the most thoroughly and effectively on stage. All of the bands that enter this competition are outstanding and reflect the outstanding leadership provided by their directors. The judges are not trying to decide which is "the best" band. I’ve been recording the classical music evenings at the Sunflower Music Festival at White Concert Hall at Washburn University in Topeka for many years and last summer was the first time I’ve had a chance to have a multi-track recording of the jazz night. The band director then puts all those parts together paying particular attention to dynamics, feel, balance, blend, intonation, articulation and time.īands who accept this challenge and are able to display the evidence of their due diligence on stage are usually the most successful. Deborah Brown Live at the Sunflower Music Festival June 21, 2021. This puts much onus on each individual musician to do their homework to be able to emulate their part in the score as well as their solos. We hope that each band, as an ensemble, but additionally each individual band member, embraces the challenge of dissecting the composition and studying the interpretation of the artists' who originally performed the music. The point of making "Basically Basie" a competition is to give bands the motivation to delve deeply into their chosen repertoire. Particularly with bands here in Kansas City, we feel it is important that our students understand, appreciate and take pride in the unique jazz legacy that many musicians, but particularly Count Basie, bestowed on our town. The "Basically Basie" competition is modeled after the "Essentially Ellington" competition in which bands select approved repertoire and work toward emulating the style and spirit of the music as closely to the original performances and recordings as possible. Lee Langston Join us at PVs Harmon Park Saturday, September 9 to celebrate 12 years of world-class jazz in. There is also a non-competitive category (Summit) that allows bands to showcase their own unique style and personality. 7:45 p.m.: The Kansas City Jazz Orchestra feat. The Folk Alliance International Conference, presented by Folk Alliance International, is the world’s largest gathering of the folk music industry and community (crossing a diverse array of genres including Appalachian, Americana, Blues, Bluegrass, Celtic, Cajun, Global Roots, Hip-Hop, Old-Time, Singer-Songwriter, Spoken Word, Traditional, Zydeco, and various fusions). Bands are judged on their ability to capture the essence of the Kansas City style as best exemplified by the Count Basie Orchestra. The festival highlights Kansas City's rich jazz heritage through the "Basically Basie" Jazz Heritage Competition. The Kansas City Jazz Summit provides an educational performance opportunity for middle school, high school and college jazz bands, combos and jazz choirs and takes place in April each year at Kansas City Kansas Community College. ![]() ![]() ![]() By linking your account with pubg Twitter, players can invite their Twitter friends to play arena with you.The first benefit of connecting with Twitter is the regular saving of your social media platform’s progress.How to unlink pubg mobile from Twitter? Benefits of linking account with Pubg Twitter support Here, players can see the logos of earlier connected accounts as well as the Twitter logo. After authorizing, go back to settings and again check the linked account with pubg mobile.Press on the authorize app tab by doing this, you can read tweets, see followers, and update your game progresses on your pubg Twitter account.After login into the Twitter account, again, a confirmation tab will open for Authorize PubgMObile to use your Twitter account for Pubg Twitter.Don’t worry if you don’t have an account on Twitter you can sign up for the Pubg Twitter account through the same authorization page’s sign-up option. If you already have an account on Twitter on this page, you can quickly log in through your official Twitter account. ![]() After pressing OK, players can redirect to Twitter pubg support page for authorization and further options.This option confirms the deletion of your saved data on an earlier account and transfers it to pubg Twitter. On this confirmation, tab click on OK.Press on the Twitter account then a confirmation tab opens for confirmation for earlier accounts unlinking.After opening more options, you can see options like Facebook, Twitter, and WeChat.Click on the ‘More’ option below the linked account. Here, you can see your latest linked account or guest account option to connect with the Twitter Pubg.After opening the setting, check your linked option and check which account is linked with it, like Facebook and Google PlayStore.First of all, go to the game setting in the top right corner of the main menu.There is a step-by-step guide on how to link a Twitter account with Pubg Twitter. ![]() To get this feature for Pubg support Twitter, users have to connect their gaming account with Twitter. Furthermore, the new update of the Pubg game allows linking multiple guest accounts with Twitter. So, the Pubg via Twitter linked your account for updating your progress on the online platform. Pubg supports Twitter is those iPhone users who can’t access the Google player account to update their progress. To be a part of this developer team, you have to make some changes in your Pubg to get Pubg help Twitter. After getting the feedbacks, the feedbacks developers make significant improvements for further updates. PUBG Twitter support uses this option as a survey to get feedback on new features and game improvements. Moreover, players who registered on a Twitter account can try new beta version features without official launching. This game is viral due to its real-time graphic design and helps feature to connect with friends via the help of Twitter. It is very famous worldwide and played by every age of people for entertainment purposes. PUBG is a multiplayer online game and abbreviated as Player Unknown Battle Ground. ![]() ![]() I was really close to Nice," Debuchy said. "As of this moment, I still don't know why it didn't come through. With Arsenal willing to allow him to leave, the deal appeared set to be completed only for Nice to finally bring in fellow France international Christophe Jallet instead. I'm open."ĭebuchy had already expected to return to Ligue 1 when Nice made a serious approach for him last summer. The former Lille man would not rule out a return to France despite a disappointing loan spell at Bordeaux in 2016, saying: "We'll see if there are good opportunities in the transfer window. The fact I'm playing well will give me opportunities," Debuchy said. "I want to leave, to find a new challenge in January. ![]() Mathieu Debuchy has told RMC Sport he is determined to move on from Arsenal during the winter transfer window.ĭebuchy, 32, arrived at the Emirates Stadium from Newcastle in 2014 as one of the Premier League's top right-backs and pushing to become France's first-choice in the position.Ī serious ankle ligament injury sustained barely a month after making his competitive debut for Arsenal ruined his ambitions, however, as Hector Bellerin seized the opportunity to move ahead of him in Arsene Wenger's plans.īut while Debuchy made his first start in almost a year in the Europa League game against Red Star Belgrade in October, and has made a total of six appearances in cup competitions this season, he remains hopeful of not seeing out the final 18 months of his contract in North London. Mathieu Debuchy: I want to leave Arsenal in January transfer window ![]() You have reached a degraded version of because you're using an unsupported version of Internet Explorer.įor a complete experience, please upgrade or use a supported browser ![]() |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |