![]() ![]() In the training cohort, the areas under the curve were 0.708 for 3-year survival and 0.704 for 5-year survival. The time-dependent receiver operating characteristic curve analysis suggested that the 8-gene signature had a good predictive accuracy. Results In this prognostic study based on samples from 1096 women with BC (mean age, 59.6 years), 8 DRGs ( MDC1, RPA3, MED17, DDB2, SFPQ, XRCC4, CYP19A1, and PARP3) were identified as prognostic biomarkers. To examine the potential mechanisms of the DRGs, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed. Finally, a prognostic nomogram, combining the DRG signature and clinical characteristics of patients, was constructed. A risk model was completely established through multivariate Cox proportional hazards regression analysis. Main Outcomes and Measures Primary screening prognostic biomarkers were analyzed using univariate Cox proportional hazards regression analysis and the least absolute shrinkage and selection operator Cox proportional hazards regression. A prognostic signature based on 8 DNA repair–related genes (DRGs) was developed to predict overall survival among female patients with BC. This study consisted of a training set from The Cancer Genome Atlas database and 2 validation cohorts from the Gene Expression Omnibus, which included 1096 patients with BC. Objectives To identify a potential DNA repair–related prognostic signature through a comprehensive evaluation and to further improve the accuracy of prediction of the overall survival of patients with BC.ĭesign, Setting, and Participants In this prognostic study, conducted from October 9, 2019, to February 3, 2020, the gene expression profiles and clinical data of patients with BC were collected from The Cancer Genome Atlas database. Currently, identifying effective prognostic models has a significant association with the prediction of the overall survival of patients with BC and guidance of clinicians in early diagnosis and treatment. Importance Breast cancer (BC), a common malignant tumor, ranks first among cancers in terms of morbidity and mortality among female patients. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography. ![]() The Functional Enrichment Analysis Included KEGG Pathway (A) and Biological Process (B) The functional Enrichment Analysis Included GO Pathway (A) and Biological Process (B)ĮFigure 6. The Calibration Plots for Predicting Patient 3-Year (A) and 5-Year (B) Overall SurvivalĮFigure 5. ROC Curves and Kaplan-Meier Plots of Overall Survival in External Validation CohortsĮFigure 4. Eight DRGs Were Selected to Construct Prediction Model by Multivariate Cox Regression AnalysisĮFigure 3. Heatmap of Differentially Expressed Genes Between BC Tissues and Normal ControlsĮFigure 2. KEGG Pathways Enriched in High-Risk and Low-Risk Groups by Using GSEAĮFigure 1. The 33 DNA Repair-Related Genes Identified Through the Univariate Cox AnalysisĮTable 6. Clinic Pathological Characteristics of Extracted Patients With Breast CancerĮTable 5. Checklist of Items for Reporting a Study Developing or Validating a Multivariable Prediction ModelĮTable 2. ![]()
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